The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation
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منابع مشابه
Bacteriocin production by Clostridium acetobutylicum in an industrial fermentation process.
High titers of a noninducible bacteriocin were produced by Clostridium acetobutylicum in a molasses fermentation medium used for the industrial production of solvents. Release of the bacteriocin towards the end of the exponential growth phase was accompanied by lysis of the culture and inhibition of the production of solvents. The producer cells were sensitive to the bacteriocin, which only aff...
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The purification and concentration of enzymes by adsorption on charcoal, tannin, aluminum hydroxide, ion exchange resins, and so forth, has been an established practice in the laboratory. Some years before this work was done in 1949, alkali-cooked lignin was used as an adsorbent for mold and malt amylase (Wallerstein et al., 1945). In this paper is described our study of the adsorption of the a...
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Iron is a nutrient of critical importance for the strict anaerobe Clostridium acetobutylicum, as it is involved in numerous basic cellular functions and metabolic pathways. A gene encoding a putative ferric uptake regulator (Fur) has been identified in the genome of C. acetobutylicum. In this work, we inactivated the fur gene by using insertional mutagenesis. The resultant mutant showed a slow-...
متن کاملCellulolytic Activity of Clostridium acetobutylicum.
Clostridium acetobutylicum NRRL B527 and ATCC 824 exhibited extracellular and cell-bound endoglucanase and cellobiase activities during growth in a chemically defined medium with cellobiose as the sole source of carbohydrate. For both strains, the endoglucanase was found to be mainly extracellular (70 to 90%) during growth in continuous or batch cultures with the pH maintained at 5.2, whereas t...
متن کاملMetabolic engineering of Clostridium acetobutylicum for the industrial production of 1,3-propanediol from glycerol.
Clostridium butyricum is to our knowledge the best natural 1,3-propanediol producer from glycerol and the only microorganism identified so far to use a coenzyme B12-independent glycerol dehydratase. However, to develop an economical process of 1,3-propanediol production, it would be necessary to improve the strain by a metabolic engineering approach. Unfortunately, no genetic tools are currentl...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01809-5